Tuberculosis (TB) is one of the most severe contagious diseases particularly in the developing countries1. Isoniazid (INH) was used in 1952 for the first time as an anti-TB agent. It is a chemoprotective agent which is effective due to its low minimum inhibitory concentration against TB causing bacteria2. It has a protective role in prevention and treatment of TB3. Unluckily, the treatment course of therapy using INH is convoyed by undesirable side effects such as hepatotoxicity4.
In the previous studies the potential hepatoprotective role some natural extracts was investigated on the basis of their antioxidant properties. Protective role of Milk thistle against TB causing microorganism was found by Eminzade and team5. The ameliorative role of fish oil extracts also on the hepatotoxic effects of INH and rifampicin (RMP) in rats was reported by Basheer and his team6.
Despite these studies, the quest for finding alternate and safer natural products never ends. Researchers are taking interest in Flavonoids and testing them against many disarrays. They have active photochemicals that have promising roles against various health intimidating compounds7. This makes them if great interest for many studies.
Naringenin (NGN) one of dietary flavonoid, abundantly found in grapefruit, orange and tomato. It possesses anti-carcinogenic, anti-inflammatory, antioxidant, hypolipidemic and hypoglycemic effects on the biological systems8. Researchers conducted a novel study to investigate the probable protective role of NGN against the INH-induced adverse effects on certain hematological criteria, serum biochemical and hepatic oxidative stress parameters, in male albino rats9.
100 rats were randomly divided into 4 groups having; the control group, INH-treated group, (INH+NGN)-treated and NGN-treated group. Certain hematological parameters, hepatic function markers, lipid and protein profiles in serum as well as the lipid per-oxidation and endogenous antioxidants content in the liver were analyzed. The INH and NGN were orally administered at dose levels.
The administration of NGN prior to the treatment with INH had protected the liver and effectively barred the adverse actions of the INH on all the studied hematological and biochemical parameters. Moreover, the treatment with NGN alone did not induce any significant changes in all the studied parameters, as compared to the controls except for a marked reduction in the levels of TL (total lipids), TC (total cholesterol) and LDL-C (low-density lipoproteins) that highlighted its hypolipidemic action.
It can be established that the INH administration to Wistar rats, at a high therapeutic dose level, could induce a hepatic injury in addition to certain hematologic and metabolic alterations. Yet, the pretreatment with NGN could ameliorate these alterations via its anti-oxidative effect.
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30 March, 2020