Human life span is expected to be 65 years only by 2025. It has been reported in literature several times that aging causes the immune system to get weaken1. Aged people are more prone to losing proper immune regulation in their innate immune system2.
In previous studies it was demonstrated that a model of natural aging effect in various tissues of rodents can be induced by subcutaneous injection of D-galactose3. Therefore, a model induced by D-galactose (a monosaccharide sugar) aging can be a suitable model for age-related research.
Bergapten is found in bergamot essential oil, in other citrus essential oils, and in grapefruit juice along with various other plants like figs and parsley. Biological studies have found that this plant posses anti-proliferative, anti cancer, antidepressant, anti-oxidative and anti-inflammatory properties4, 5.
Scientists performed a study in which they investigated the molecular mechanism and underlying interactions of bergapten with immune responses to age-related changes. Bergapten was applied to treat mouse models of aging-induced immune deficiency, based on the optimal proportional allocation. The immune-modulator effect of bergapten was investigated6.
Before start of experiment the survival test was performed on mice with bergapten treatment. Male mice were separated into normal or D-galactose-induced aging model. Production of serum cytokines such as anti-oxidant enzyme and malondialdehyde (MDA) were determined. Flow cytometry analysis and enzyme activity assays were used. Modulator effects of bergapten on T cell proliferation were also investigated.
It was found that bergapten treated group, the body weight and spleen index was reversed. It also promoted the T cell proliferation in aging mice. It also enhanced enzyme effects which elinitaed the virus in old age.
It was thus established bergapten therapy can modulate immunity against viral epidemics and attenuate aging-induced immune deficiency. These effects may be attributed to the activation of the Th and Tc responses in D-galactose induced aging Balb/C mice.
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17 November, 2019