Zinc oxide nano-particles (ZnO NPs) are considered one of the excellent metals that are used in different areas as an antimicrobial and optical agent. Different compounds have been used for green synthesis of ZnO NPs and have revealed improved therapeutic properties. This indicates the use of ZnO NP as potential nano antibiotic or drug carriers for drug delivery to the target cancer cell1.
Previously, ZnO NPs with green tea extract has been studied by many investigators2. They found that polyphenolic and catechin compounds exist in green tea had intrigued a lot of interest due to their benefits to human health and their antioxidant capacity. The complex can be used against several patho-physiological conditions as hypertension, cardiovascular disease, dementia and even cancer3.
Monosodium Glutamate (MSG) is used to improve the taste in food. However, the long-term use of MSG can induce oxidative stress4. MSG intake has many side effects on the brain, obesity, sex organs and metabolism. It can cause disturbances in metabolism with the increase in insulin, fatty acids and triglycerides in serum. It affected the liver function resulting in elevation of transaminases’ levels and bile synthesis, it also led to oxidative stress in liver and to the pathological changes in ovaries and fallopian tube5.
Therefore a new study was carried in order to evaluate the efficacy of the anti-hyperlipidemia effects of green tea leaves extract (GTE)/ZnO NPs complex against monosodium glutamate6. The alteration of enzyme activity of liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALK) and γ-glutamyl transferase (γ-GT)] and lipid profile alternation was demonstrated.
It was found that hyperlipidemia, induced by MSG-treatment caused the marked elevation in all parameters of the lipid profile except HDL-C which was declined. Moreover, the disturbance of lipid profile was auxiliary with elevated markers of liver function as in the present study and histological alternation. In the liver injury, the hepatocytes are disturbed and resulting in the elevation of the serum liver enzymes.
GTE/ZnO NPs complex has been settled biochemically as an antioxidant which ability to scavenge the free radicals (superoxide, hydrogen peroxide and hydroxyl) and decline the oxidative stress. Moreover, it protects the architecture of the liver against different doses of MSG3. Hence, the rats in the group treated with GTE/ZnO NPs complex and MSO showed the decrease in the enzymes activity and lipid profile as compared to MSG alone7.
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18 August, 2019