Diabetes mellitus (DM) is considered as a silent killer and root cause of several diseases. It is basically a chronic metabolic ailment, that is caused due to inadequate or no production of insulin from pancreas which leads to higher blood glucose level. Unfortunately up till now, proper and complete treatment is unavailable to treat type 2 DM1.
Accordingly, numerous medicines, α-glucosidase inhibitors including acarbose, voglibose as well as miglitol are obtainable now to cure post-prandial hyperglycemia. This is a condition in which amplified rise in blood sugar level occurs after having a meal in people are not suffering with diabetes because secretion of insulin from pancreas all the time. But, these drugs leave negative impacts including yellow eyes or skin and gastrointestinal disturbances. Therefore, substitute of these drugs is needed to treat diabetes2.
In this regard mushroom polysaccharides are significant. Polysaccharides extracted from natural plants possess less toxicity, little side effects as well as stimulatory activities3. According to recent investigations, polysaccharides exhibit outstanding immune-enhancing activity. Moreover, the biological activities of these compounds depend on their structural properties (the glycosidic bond of the major chain sugar subunits)4.
Accordingly, Agaricus bisporus is a well known edible mushroom, also known as common mushroom, button mushroom or white mushroom as well. It consists of trace elements such as sodium, potassium, phosphorus and common antioxidants vitamin C, phenol compounds as well as flavonoids. Moreover, Ergosterol present in A. bisporus lessens the risk of breast cancer.
Therefore, research team lead by Periyanan Muni5 got motivated to investigate the in vitro antidiabetic activity of polysaccharides from Agaricus bisporus. For this purpose, scientists characterized the extracted polysaccharides through 1H NMR, 13C NMR spectroscopy. Moreover, their in vitro antidiabetic activity was examined via α-amylase inhibitory activity. Afterwards, SPSS version 16 was employed for statistical study.
This research revealed satisfactory outcomes as extracted polysaccharides exhibited considerable antidiabetic activity. Therefore, scientists suggested that A. bisporus polysaccharides could be a potential source of natural antidiabetic as it possesses certain health benefits. Conclusively, mushroom polysaccharides can aid to cure multiple human disease syndromes linked with allergy, cancer, diabetes and other infections etc.
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17 November, 2019