Cancer is a chief cause of death globally and is prevailing like a death angel in many regions of the world. Moreover, oral cancer is considered as the 3rd most common cancer and major reason of death among men worldwide1. Chemoprevention is a novel approach now a days, against cancer and majority of the anticancer compounds are phenolic acids which play a key role in antioxidants as chemoprevention2. Natural therapeutic drugs are gaining attention of experts and discovery of efficient anti-cancer drugs from natural resources are crucial regarding cancer chemotherapy3.
Currently, nanotechnology is found to have the potential to alter the methods of cancer diagnosis and treatment. Nanoparticles have the ability to detect cancer at its initial stages, finding its location in the body and transferring anticancer drugs particularly to malignant cells4. Sinapic acid is a cinnamic acid derivative which carries 4 hydroxy 3, 5 dimethoxycinnamic acid and is considered as one of the phenolic acids broadly found in edible plants including cereals, nuts, oil seeds as well as berries5. Sinapic acid prevents oxidative stress associated ailments, like atherosclerosis, inflammatory injury and cancer6.
In this regard Gehan Abdel Naser and team performed a research to determine the cytotoxicity of free and Nano-sinapic acid on squamous cell carcinoma (HEp-2) and to check the cytotoxicity using MTT assay, evaluation of morphological changes post cell treatment with free and Nanocapsulated Sinapic acid. Nanocapsulation was conducted through Tween-80 and assessment of cell apoptosis as well as related pro and anti apoptotic genes was done by utilizing rt-PCR concerning (Bax and BCl-2) and cell apoptosis procedure. At last, geno-toxicity was traced by means of arranging for flow cytometry.
Scientists noted that Sinapic acid have the cytotoxic effect against cancer cells and have potential to be used as effective new candidate for cancer chemoprevention. Whereas Nano- sinapic acid exhibited more cytotoxic impact on cancer cells with less concentration as compared to sinapic acid so it could perform better as novel candidate in case of cancer chemoprevention.
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17 November, 2019