Viruses of prokaryotes are significant and diverse forms of nature. They represent most of the organisms present on the planet and have an important role in the evolution of their bacterial as well as archaeal hosts. They have been doing this job for billions of years, perhaps for as long as there have been cells1. However, the viruses which infect the archaea comprise a small portion of total viruses. Most of these viruses, particularly those that infect hyperthermophilic hosts are unique and different morphologically such as bottle shaped, spindle shaped, droplet shaped, coil shaped and bacilli form2.
Mostly, these archaeal viruses possess double stranded DNA and only a few carry single stranded DNA. Moreover, they were now considered to represent the supreme reservoir of genetic diversity on the planet due to their abundance as well as variety3. Archaeal viruses are also considered important numerous main evolutionary transitions, such as the invention of DNA as well as DNA replication mechanisms4.
Hence, it is interesting to study the genome of these viruses. Accordingly, Genometrics is a useful in silico method to examine the DNA sequences of any organism. But, stilly there is no dedicated database to investigate the comparative genomics of all archaeal viruses5. Therefore, scientists have developed ArchaeVir database to study and compare the Z-curve as well as cumulative amino and keto skews of all sequenced archaeal viruses. It is reported that the Z-curve has the potential to spot the replication origin in many prokaryotes6, particularly in numerous archaea7.
Accordingly, Krishna Kumar , Swapnil Mishra and Lalit Kumar8 designed a research and used biometric method (ArchaeVir database) to recognize the local and global characteristic of nucleotide distribution in all available archaeal genomes on Genbank. For this purpose, all archaea viruses’ genomes were downloaded from NCBI. Then, scientists wrote a script in MATLAB to analyze and plot the cumulative Z-curve and nucleotide skews. Afterwards, database was created by means of MySQL and PHP, AJAX .
Scientists found that Archaevir is the first database which is effectual and has investigated all archaeal virus genomes for Z-curve along with amino-keto and purine pyrimidine skews with their basic genomics record like between genome length and protein, total gene, nucleotide distribution etc. Conclusively, data available on this database can be helpful for researchers to understand the local and global genometric feature of archaeal virus genomes.
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18 August, 2019