Free radicals are responsible for several human diseases and this problem is being increased due to smoking, environmental pollution, ultraviolet radiation, drugs, pesticides, anesthetics as well as industrial solvents. In response to free radicals human body utilizes antioxidants for its natural defense mechanism1. Antioxidants refer to the substances which considerably holdup or prevent the oxidation of oxidizable substance2.
Medicinal plants are valuable sources of antioxidants and many other useful products. These plants are which possess substances useful for therapeutic purpose or which can be utilized as precursors to manufacture antimicrobial, antioxidant, anti-infectious and anti-tumor drugs3. Moreover, herbal medicines generated from these plants are effective, affordable, less toxic and acceptable.
Salvadora persica is important in this regard. Generally, it is used as a tool for teeth, tongue and gum cleaning and to cure toothache as well4. The phytochemical screening of its extracts showed the presence of carbohydrates, glycosides, sterols, terpenes, flavonoids, tannins and alkaloids in herbaceous part of the plant but, saponins, coumarins and anthraquinones are deficit5. It is reported that Tannic acid, Sulfated compounds, benzyl isothiocyanate, liriodendron and salvadoracine carry antimicrobial properties to cure gum inflammation. Additionally, glycosides are also important because they are employed as medications like antioxidant, anti-inflammatory, laxative, analgesic and heart diseases6.
Accordingly, Kedir Ebrahim and Alemayehu Mekonnen7 designed an experiment to assess total flavonoid and polyphenol contents, antioxidant and antimicrobial activities of ethanol extracts of root as well as stem parts of the S. persica. For this purpose, scientists performed the extraction by means of maceration procedure. Total phenolic content, total flavonoid content and antioxidant activity of this plant were then examined by means of the Folin ciocalteu, the aluminum chloride colorimetric and reducing power (FRAP) assays, respectively. Later, the agar well diffusion procedure was applied to check antibacterial activity.
At the end of this investigation, root and stem extract of Salvadora persica were found to contain evident concentration of total phenols and also the little amount of flavonoids which is crucial to control oxidation. Conclusively, these findings confirmed the efficiency of S. persica root and stem extracts for its outstanding antioxidant as well as antimicrobial activities. This research will ultimately help to introduce this plant as a natural therapy against certain diseases in future.
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17 August, 2019