Hemoglobinopathy is inherited single-gene disorders that results in abnormal structure of one of the globin chains of the hemoglobin molecule. Increased adhesiveness of the white blood cells, platelets and other sickled cells to the endothelium of blood vessels is a major cause of haemoglobinopathies1. Haemoglobinopathies is associated with cardiovascular ailments and hypercoagulability with a elevated chance pulmonary hypertension, stroke and complications during pregnancy, which may occur because of thrombotic vascular occlusion (thromboembolism)2. Thromboembolic complications are also noted in patients suffering with thalassemia.
Treatment of hypercoagulability and thromboembolic complications linked with haemoglobinopathies is challenging for physician. The purpose of drugs (hydroxyurea and opioid analgesics) given to these patients; is to lessen the vaso-occlusive painful episodes, hypercoagulability, thromboembolic complications, joint inflammation and to relieve pain. But, these medicines carry various negative impacts on leucocytes, platelets, immunodeficiency as well as male infertility in few patients3.
Therefore, focus on herbal treatments e.g. Polyherbal formulations (PHFs) is increasing that have anti-inflammatory, anti-thrombotic and antioxidant attributes to prevent various disorders including haemoglobinopathy complications. The PHFs contains 5 plants (Hunteria umbellate, Calliandra portoricensis, Kigelia africana, Lagenaria breviflora as well as Nauclea latifolia), having antidiabetic, analgesic, antispasmodic, antipyretic, immuno-stimulatory properties4, antihyperlipidemic, anti-thrombotic5, anti-inflammatory, anxiolytic as well as antioxidant6 activities.
Accordingly, Akinbo B. David, Bamisaye E. Oluwaseyi and Nimi-Johnson E. Ebietein designed a study to check the impact of a polyherbal formula on endothelial dysfunction, coagulation indices and inflammation in 2-butoxyethanol-induced experimental model of haemoglobinopathy in adult rabbits. For this procedure; scientists selected twenty healthy rabbits randomly and divided them into groups. 12 rabbits received 2.5 mL kg–1 of 2-butoxyethanol per os (p.o) and 1 mL kg–1 of 100 mg mL–1 polyherbal formula for fifteen days, respectively pre- and post-2-butoxyethanol administration whereas the remaining 6 rabbits were grouped as control. Afterwards, the levels of coagulation indices, inflammation marker and platelets were assessed. Moreover; tissue histology was utilized to check the expression of microvascular occlusion as well as ischaemia.
Scientists noted that polyherbal formulation didn’t exhibit any metabolic toxicity and was capable to prevent 2-butoxyethanol-induced hypercoagulability as well as circulating thrombose, endothelial and inflammatory perturbation in rabbits when administered for fifteen days before and after exposure to the 2-butoxyethanol induced haemoglobinopathy complications.
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17 November, 2019