The American Psychological Association (APA) defines anxiety as “an emotion characterized by feelings of tension, worried thoughts and physical changes like increased blood pressure.” It is a complex behavioral and physical alteration leading to certain Central Nervous System disorders if remain untreated.
Traditional resource like many herbal plants is in great demand for manufacturing many pharmaceutical products so why not the natural and synthetic herbal molecules preferred to treat such disease with fewer side effects and less cost1.
The only problem faced during their commercialization of herbals is standardization and purity of compounds. These herbals also preferred due to fewer withdrawal effects to the patients during treatment2.
Anxiety is an emotional state with imbalance of neurotransmitters like Gamma Amino Butyric Acid, serotonin and leads to feeling of discomfort, concern or fears to define or undefined objects/situation.
Lagenaria siceraria, commonly known as calabash, bottle gourd, or white-flowered gourd is an annual herbaceous climbing plant with a long history of traditional medicinal uses in many countries. Since earliest times, this plant has been known for its curative properties and has been utilized for treatment of various ailments, including jaundice, diabetes, ulcer, piles, colitis, insanity, hypertension, congestive cardiac failure (CCF) and skin diseases.
In previous studies it was reported for various pharmacological activities like Diuretic analgesic, anti-nflammatory, anti-hyperlepedemic, antithelmentic, anti-hepatic, Immuno-modulatory, anti-microbial and anti-oxidant moreover in neurological disorders3, 4.
Keeping in view all these pharmacological uses scientists decided to look for its anti-anxiety potential and it had been shown to treat neurological properties. Researchers used three animal models of anxiety to evaluate the anti-anxiety effect of Lagenaria sicereria extracts5.
Three well established rat models were selected for evaluation of anxiety in rats. The protocol was designed by giving drugs for seven days and various behavioral parameters like Time spent in the open and closed arm, No. of entries in each arm, Latency, Time spent in light and dark compartment, No. of crossings, Immobility, Sniffing, Crawling and Aggressive behaviors were evaluated. At the end of an experiment, all animals were subjected to dissection and serotonin and GABA levels were determined in brain tissues.
The methanolic extract of bottle gourd extracts revealed that it possesses a therapeutic effect against anxiety disorder. The Rats treated with it showed significant changes in behavioral and mobility in all three models during experiment.
Authors of study said about future recommendations:
“On the basis of results obtained in our study, the following future findings may be summarized:
Additional studies with diverse extracts and their fractions are expectant to identify the chemical components responsible for anti-anxiety activity. Also clinical studies to prove this effect is also needed for its applicability in humans for treatment of anxiety disorder. Thus all the results pave a way for further research, must be carried out to explore the golden use of plant in neurological disorders.
Written by: Rabeeia
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26 May, 2019