Scientists have investigated calcium carbonate isolated from Brachidontes variabilis shells (Marine species) and found that these shells certainly have significant potential in clinical transformation. This can further subjugate for competent making of diverse therapeutic policies1.
Calcium is a vital structural constituent of teeth and bones that is required for the normal functioning of all nerves and muscles. Calcium carbonate is a bio-mineral and is abundantly found in nature. It is extensively used as a dietary calcium supplement worldwide2.
The coral skeletons are generally thought to be made of aragonite because of Ca/Mg molar ratio of seawater. This helps in the deposition of calcium carbonate. CaCO3 is considered as a potential inorganic precursor to induce the formation of bone minerals2.
Osteoporosis is complete diminishing of bone amount, leading to fractures after minimal trauma3. Calcium decline is probably because to reduced intestinal calcium absorption, insufficient dietary calcium intake, as well as increased urinary calcium loss associated with estrogen deficiency4.
Marine products rich in calcium turned out to be potential supplements used in combination with medication for osteoporosis treatment. Scientists studied the use natural products extracted from marine organisms in osteoporosis treatment as novel approach in drug discovery.
Researchers performed a experiment in which they used the calcium carbonate isolated from Brachidontes variabilis (B. variabilis) shells against bone loss in ovariectomized (removed ovary) rats.
It was found that the best methods for structural identification of calcium carbonate are; X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Proximal, distal and total bone mineral density was increased in ovariectomized rat model. Several serum levels were elevated like osteoprotegerin. Overall bone absorption and bone formation genes were significantly improved.
All the above observation make the Brachidontes variabilis shells derived calcium carbonate a potential compound having positive effects on osteoporosis in ovariectomized (removed ovary) rats model.
Written by: Rabeeia
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17 November, 2019