Caffeine 1, 3, 7-trimethylxanthine is one of the xanthine derivatives that are extensively used as diuretics.1 Diuretics or water pills, are medications designed to increase the amount of water and salt expelled from the body as urine. Caffeine 1, 3, 7-trimethylxanthine is prevalent form of methylxanthine due to its business convenience, least effort and less risk.2 The surrounding of the methylimidazole moiety in the construction of caffeine makes it an significant possibility for the blend of a N-heterocyclic carbine (NHC). Therefore, first step is to obtain an imidazolium cation, e.g. 1, 3, 7, 9-tetramethylxanthinium or methylated caffeine from caffeine. Arrangement of methylated caffeine with hydroxide2, methylsulfate1,3, tosylate3 and iodide4 anions had reported already.
Several metal complexes of xanthines incorporating caffeine in which xanthines are connected to metal by means of N-9 iota were synthesized5. The amalgamation and portrayal of two bis (NHC) copper (II) edifices 2a, 2b from methylated caffeine 1a, 1b and a dinuclear copper (II) bis (NHC) complex, 2d with the crossing over nitrate units from nitrate salt of the methylated caffeine 1d were reported6.Accordingly, the Cu (II) complexes have been constructed from the N-heterocyclic carbene ligands. Karumutchu Sitalu and colleagues performed a research in which, the Cu (II) NHC complexes were characterized by utilizing analytical and spectral methods. Scientists evaluated the antibacterial and antifungal behavior of the Cu (II) NHC complexes through reported techniques. The SOD activity was analyzed using nitrobluetetrazolium as O2 scavenger.
Researchers observed that the X-band ESR spectra of the copper complexes in DMSO solution at 300 and 77 K and recorded their prominent characters. The in vitro biological screening impacts of the compounds under observation; were evaluated against the bacterial species, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species, Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by serial dilution method.
Sitalu and team noted the square planar geometry of Cu (II) complexes. A comparative study of inhibition values of the individual metals and their complexes signify that the complexes show higher antimicrobial activity than the individual metals. Superoxide dismutase and reducing power activities of the copper complexes were also investigated in this experiment. It was also observed that the Cu (II) NHC complex exhibit promising SOD mimetic activities depending on the molecular structure. However, scientists are focusing to discover more biological characteristics of Cu (II) NHC complexes in vitro and in vivo.
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17 November, 2019