The kidneys are responsible for regulating homeostasis through balancing of electrolytes in the blood and the vital role of the cardiovascular system in maintaining homeostasis is pumping of blood. Both cardiovascular and kidney disorders are closely interconnected and illness of one organ cause disturbance in other, lastly leading to the failure of both organs. Patients with end-stage renal disease are at higher risk of death due to cardiovascular disease1.
Traditional herbal plants are used for their safety and effective results. Various chronic diseases related to kidney and heart is treated by them such as; nephrotoxicity and cardiac dysfunctions. Oxidative stress is the main implication in kidney and cardiac diseases2.
Silene villosa or Desert Campion is a desert plant generally found in Egypt, Palestine and West Iran. It was reported that alcoholic extract of S. villosa aerial part showed anti-inflammatory, hepato-protective and wound healing properties3.
Carbon tetrachloride (CCl4) causes metabolic activation in the liver endoplasmic reticulum by free radicals. All the free radical species produced by CCl4 contributes significantly to the biological disorder. CCl4 usually used as a solvent for the generation of hepatic damage by producing reactive free radicals and is responsible for kidney failure and cardiovascular dysfunction4.
There is strong evidence of cardiac and kidney organs dependency on each other for controlling mortality due to kidney failure and cardiac dysfunction. Researchers wanted to study the efficacy of desert campion plant on kidney failure and cardiac dysfunction. So they conducted a study with aim to examine the possible protective effects of S. villosa extracts on kidney failure and cardiac dysfunction using Wistar and albino rats5.
The S. villosa herbs were gathered, roughly powdered and extracted in Methanol. Wistar albino rats were randomly divided into five groups; Group I was the normal control, Group II was toxic control, Groups III was positive control, IV and V were the test groups.
CCl4 was administrated, the serum cardiac function parameters, and the serum renal function parameters were measured. The cardiac and renal tissue parameters were measured for the in vivo antioxidant activities. Further, the biochemical studies were followed by histopathological studies of heart and kidney tissues.
It was noted that the treatment of CCl4 in rats majorly changed the cardiac and kidney function test limitation. Administration of SVE showed the protective ability against CCl4 intoxication by repairing the cardiac and kidney function abnormalities. The protective ability of SVE was further confirmed by the histological study of cardiac and renal tissues.
Written by: Rabeeia
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17 November, 2019