Diabetes Mellitus (DM) is known as mother of all diseases and is one of the most threatening ailments which. It is caused as a result of raised blood glucose due to incomplete or completely absence of insulin hormone. Diabetes is associated with a lot of disorders including high blood pressure, cardiovascular and kidney ailments and UTIs etc. Urinary Tract Infections (UTIs) is infectious disease caused by various microorganisms, prevailing in women more than men. Approximately; 150 million individuals are diagnosed with UTI annually worldwide1,2. Causative microscopic organisms of UTI are gram negative microbes as Escherichia coli and Gram positive microorganisms as Staphylococcus aureus.
It is reported that diabetic patients have malfunction in bladder which prompt of urine accumulation in its pool which leads to favorable environment for the microbes to develop and cause UTI3,4,5. Factors which accelerate risk for UTIs in diabetics include age, metabolic control, length of time of DM, diabetic cystopathy, more regular hospitalization and instrumentation of the urinary tract, repetitive vaginitis and vascular complexities6,7. In addition, elevated level of glucose in the urine provides a suitable medium for development of pathogenic microbes. Scientists have proposed a lot of theories regarding this situation but association between diabetes and UTI has not been examined properly up till now8,9.
Ali Al-Asoufi and colleague designed a study to evaluate the occurrence of UTI in diabetic patients in Ma’an Governorate population of Jordan referred to the type of microbiologically confirmed UTI and pattern of the antimicrobial drugs susceptibility. During this investigation, 116 urine samples were examined to assess UTI-causing bacteria. These samples distributed unequally between diabetic male (12) and diabetic female (25) and also non-diabetic male (13) and non-diabetic female (66).
Scientists observed that E. coli is the causative agent to produce large proportion (44.8%) of UTI in both diabetic (15.5%) and non-diabetic (29.3%) patients. They noted the dissimilarity in the bacterial species; isolated from both diabetic and non-diabetic samples. On the other hand, five bacterial species including E. aerogenes, E. cloacae, C. freundii, A. baumannii and B. subtilis did not present in all diabetic samples. Treatment of UTI in both diabetic and non-diabetic patients with chloramphenicol (30 μg), ciprofloxacin (5 μg) and vancomycin (30 μg) exhibited effective outcomes as compared to the other antibiotics. Simultaneously; experts didn’t recommend cephalothin (30 μg). Scientists concluded that Escherichia coli is the prevailing bacterial infections among those samples; isolated from patients suffering with UTI. Various forms of bacterial infections seemed to be more common in diabetics as compared to other people and other infections may show more severity in patients with diabetics than in non diabetics.
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17 November, 2019