Statins are drugs which are prescribed in order to lower the cholesterol levels in the blood. By lowering the levels, they help prevent heart attacks and stroke. A new study was conducted in order to evaluate the effects of different Statins used in treatment of Hypercholesterolemia (high cholesterol levels in blood)1.
Hypercholesterolemia is a disease of lipid metabolism that is distinguished by very high cholesterol levels in the blood and increased risks of (CHD) coronary heart disease 2. Various studies show decreased the risks of CHD in patients with hypercholesterolemia receiving treatments with statins3.
Researchers performed a meta-analysis in order to determine the statins with the best efficacy. For this purpose comprehensive literature searches were established from different databases present online. Randomize controlled trials (RCTs), cohort studies or case-control studies were performed in order to have idea about efficacy of different statin drugs and dose against hypercholesterolemia.
On the whole 28 randomize controlled trials were conducted on 12855 patients. In the results of these studies it was found that total cholesterol levels were significantly reduced using a statin drug named Pitavastatin (Pit) than using Pravastatin (Pra), also Simvastatin (Sim) or Atorvastatin (Ato). The concentration of all drugs was 2mg and 20mg respectively, and
It was also found that triglyceride (TG) levels reduced using 2 mg Pit than those using 20 mg Pra. Apolipoprotein B levels were also reduced. Rosuvastatin (Ros) significantly reduced total cholesterol and triglyceride levels.
Based on the present data from 28 studies, it was concluded that 2 mg Pit or 10 and 20 mg Ros ameliorated hypercholesterolemia with greater efficacy than those with other statin drugs. The present evidence will inform further investigations and clinical selections of statins for the treatment of patients with hypercholesterolemia.
Written by: Rabeeia
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18 August, 2019