Lung cancer is one of largely occurring cancer in Chinese women and men1. Almost 1/3rd of lung cancers are the non-small cell lung cancers (NSCLC) type2. T-helper cells and T-lymphocytes have an important role in immunity during NSCLC. Natural killer T (NKT)-cells have cell-mediated controls on cancer formation. Therefore, they are considered to be symbols of cancer formation, sepsis and infections3.
The time periods of before, after and during the surgery treatments have decreased the immunity of patients. Nonetheless, epidural anesthesia has an imperative effect on immune system because it has reduced opioid (morphine type drugs) and anesthetic consumption. It also facilitates the pain control and reduces surgical stress4.
Propofol and sevoflurane have also made changes in immune responses. Therefore scientists conducted a study in order to evaluate the effect of pre-operational epidural sevoflurane and propofol anesthesia on cellular immunity of patients following lung cancer surgery5.
Researchers took 246 lung cancer patients and 2 groups were made. Anesthesia was maintained by sevoflurane in group 1. The group II was given continuous infusion of propofol. The killing activity of natural killer T-cells, western blot, T-helper cells assay, phagocytosis assay and cell proliferation assay were evaluated.
Sevoflurane had no effect and propofol had reduced the cytokines ratio. Sevoflurane had decreased and propofol had boosted the counts of T-cells, T-helper cells and killing activity natural killer T-cells. Propofol and sevoflurane both had a significant cell proliferation and phagocytosis effects.
It was established that the type of anesthetic used modulates the immunity of patients undergoing lung cancer resection.
Written by: Rabeeia
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05 April, 2020