Soybean (Glycine max) is a useful leguminous crop and is recognized as the “Golden Bean” of the 20th century1. It is reported that Soybean based foods provide numerous health benefits including inferior plasma cholesterol2, prevent cancer3, enhance bone mineral density4. Moreover they also protect against bowel as well as kidney ailments5. These healthy aspects are due to occurrence of isoflavone, saponin, protein and peptide in soybean5. According to Wang and his team, Isoflavones are class of flavonoids that exhibit estrogenic activity in mammals6. Furthermore, they also possess antioxidant, anticancer, antimicrobial as well as anti-inflammatory characteristics7.
Research team led by Dower8 as well as Grace and colleagues9 reported that the polyphenolic compounds of plant sources, especially flavonoids, exhibit anti-inflammatory activity both in vitro and in vivo models. Acccordingly, isoflavones present in soybean have numerous valuable effects on prostate and breast cancer, osteoporosis atherosclerosis, menopausal symptoms, stroke as well as neurodegeneration10. The quantity of these isoflavones consumed, food source, timing of isoflavone exposure, estrogen receptor and hormonal profile of individuals can alter the risk of breast cancer, reported by Nagata11.
Therefore, Shashank Ashokrao12 and his team conducted a research to determine the binding potential of chosen isoflavones against the possible drug targets of different types of cancer. Additionally, team aimed to assess the anti-inflammatory and antioxidant characteristics through computer assisted virtual screening method. In this experiment, scientists examined the 22 receptors for anticancer, 2 for anti-inflammatory and 3 for antioxidant investigation. Fterwards, the binding capabilities of isoflavones such as Daidzein, Genistein and Glycitein towards selected targets were evaluated via molecular docking.
At the end of this study, scientists found that isoflavones possess better interacting properties towards these cancer targets as compared to their normal ligands or predictable antitumor agents and strong approach to anti-inflammatory and antioxidant activity. Conclusively, the outcomes of this investigation will be helpful to screen and select these lead molecules as future therapeutics agents against cancer.
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17 November, 2019