Long term alcohol consumption may cause in several health disorders such as malnutrition, sleep problems, even liver cirrhosis and ALD Alcoholic Liver Diseases1. Alcohol related diseases are getting quite common and is cause of high death rate due to liver injury2. ALD is regulated by many pathways such as; alcohol induced oxidative stress, lipid per-oxidation, free radicals generation and inflammation3.
Keeping in view the fact that alcoholic diseases are caused by oxidative stress so these can be reduced by using antioxidant compounds4. Therefore, the predominant source of antioxidants and their role in preventing ethanol-induced liver injury is an important target.
Platycodi Radix (PR) is the dried roots of Platycodon grandiflorum. Traditionally it is used food and medicine for asthma and bronchitis in China5. It has been reported to possess many pharmacological active ingredients such as; as triterpenoid saponins which exhibiting the treatment of metabolic diseases including obesity, hyperlipidemia, tumor, inflammatory and diabetes6. It has also showed protective effects on alcohol induced injury in animal models7.
Steaming and heat changes may cause increased activity of roots; many studies have previously said that8. This led the scientists to perform a study whether steamed Platycodi Radix has protective effect on acute alcohol-induced liver injury in mice. Importantly, the change of constituents between the steamed and un-steamed one was observed for the first time. Moreover, LC/MS analysis was employed to determine the chemical constituents from SSPR and 22 saponins and lobetyolin were identified9.
Authors conclusively said that:
“Our findings suggested that steamed PR has protective effects on the liver against oxidative damage caused by alcohol exposure, possibly via inhibiting lipid accumulation and per-oxidation and preserving the antioxidant defense system. Thus, SSPR might be a potent natural ingredient for the prevention of oxidative stress–induced liver diseases. The molecular mechanism of action underlying interactions involving oxidation stress, lipid accumulation, fatty degradation and liver cells apoptosis with SSPR will be further investigated in future.”
It was the first report on the hepato-protective effect of steamed Platycodi Radix (PR) and the facts evidently elucidated that steamed PR at the discovered dosage has an explicit liver protective effect. Moreover, comparative with the previous studies of Platycodi Radix, the presented findings further elucidated that steaming method can significantly increase the content of active compounds.
Written by: Rabeeia
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23 August, 2019