Increase in elderly populations may cause socioeconomic problem worldwide. Among this socioeconomic burden the increasing cause is the cognitive dysfunction in aging individuals. This Mild Cognitive Impairment (MCI) leads to memory loss and dementia.
The anticipated occurrence of MCI in individuals of age 60 years and older is about 15-20%, which has a 10% chance to convert into dementia within a year1. This lead to early treatment and prevention of age related cognitive mutilation. Until today except for the discovery of cholinesterase inhibitors no other effective treatment had been discovered2, 3.
Wheat is principally composed of starch, proteins and dietary fibers including arabinoxylan and β-glucan4. In earlier animal study it was revealed that supplementation with wheat water extract (WB) and wheat bran water extract (WBE) improved visuo-spatial working memory in a rodent model of Alzheimer’s disease (AD) by exerting neuro-protective effects and promoting the expression of neuro-trophic factors5.
Moreover it has also been previously demonstrated that WB and WBE had similar behavioral effects and reduced white matter injury in a rodent model of vascular dementia (VaD)6. These previous findings suggest that WBE may have utility for supporting healthy cognitive function or for improving cognitive impairment in aging individuals.
So scientist performed a randomized controlled trial of WBE was performed to examine the safety and efficacy of WBE for the treatment of cognitive impairment in older adults with subjective memory impairment7.
Researchers randomly selected 70 participants aged between 50 to 80 years having subjective memory impairment. Neuropsychological assessments included the Computerized Neuro-cognitive Function test (CNT), Working Memory Test (WMT), Brief Cognitive Rating Scale, Prospective and Retrospective Memory Questionnaire, Perceived Stress Scale.
It was revealed that Visual learning test (CNT) scored higher in the WBE group. Moreover, participants in the WBE group showed decreased reaction times in the visual subtest of the WMT. There were no adverse events related to WBE consumption.
Conclusively it was established that that WBE supplementation can improve cognitive function safely, especially visual memory, in older adults with subjective cognitive impairment.
Written by: Rabeeia
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23 August, 2019