In a new study scientists have discovered the effective amount of licorice extracts’ dose taken for bronchial asthma and investigated its side effects against different parameters1.
Licorice is the root of Glycyrrhiza glabra that has been widely used in the folk medicine for centuries. Previous experimental and clinical reports proved therapeutic properties of licorice multiple times. It can treat various diseases such as; from the common cold to liver illnesses and in the treatment of respiratory diseases, such as cough2.
A previous report demonstrated the potential capacity of the licorice for the treatment of bronchial asthma3. It contains anti-inflammatory and anti-oxidant properties that are accredited to its major active constituent, glycyrrhizin4.
Bronchial asthma (BA) is one of the broadly established chronic lung diseases amid all ages. To date this is the disease with no proper hampering and treatment2. Reactive oxygen species (ROS) and inflammation have been shown to be directly associated with BA4. Allergen-specific CD4+ T cells were established to possess a key role in the pathogenesis of BA5.
Strong anti-inflammatory corticosteroids are the most efficient medicines existing for BA treatment6. Nevertheless, these drugs are not fully suitable and some concerned side effects like adrenal function disturbance and global immune suppression. Due to fatal nature of this disorder and lack of ultimate prophylactic and therapeutic medications lead up to 60% of patients to look alternative therapy7.
Connecting these dots scientists conducted an experiment in order to evaluate the effect of three different doses of licorice extract on lung pathology and effect of oxidative markers in an artificially induced BA animal model1.
For this purpose mice were used and divided into 6 groups having different dosage of licorice. It was found that lowest dose of licorice protected against disease. Oxidative markers were also reduces. The lowest dose of licorice is the most effective and as the dose increases the antioxidant and anti-inflammatory action decrease. This provides an advantage as licorice has many side effects which appears with the high doses.
Written by: Rabeeia
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17 November, 2019