Oxidative stress is basically an imbalance between the production of free radicals and which can leads towards cell damage. Free radicals can produce several ailments such as neurodegenerative diseases (e.g., Parkinsonism, Alzheimer’s diseases), AIDS as well as even early senescence1,2.
Body has the ability produce antioxidants to cope with free radicals, and these compounds are crucial maintain health maintenance and prevent certain chronic as well as degenerative diseases, including atherosclerosis, cardiac and cerebral ischemia, carcinogenesis, neurodegenerative disorders, pregnancy, rheumatic disorder, DNA damage and ageing as well1,3.
But, the human body generates inadequate amount of endogenous antioxidants therefore, in order to meet with the demand, exogenous antioxidants are important which are found in medicinal plants. These valuable plants possess phytochemicals which provide shield and color, aroma as well as flavor to host plants.
In this regard Desmodium velutinum has been reported to have medicinal characteristics. Extracts of this plant are utilized traditionally to treat various diseases like treatment of aches and pains4. To date, the impact of the methanolic extract stem bark on acetaminophen-induced oxidative stress has not been investigated yet. Therefore, research team led by Nkwocha Chinelo5, investigated the phytochemical constituents of the methanol extract of stem bark and their influence on some antioxidant enzymes and vitamins, in acetaminophen intoxicated rats.
In this experiment, scientists used 24 male Wistar albino rats divided them into 6 groups having 4 rats each: Group one was control, group two rats were subjected to acetaminophen and scientist intoxicated the group three rats were acetaminophen and administered them with standard drug silymarin (100 mg kg–1 b.wt.). While, rats present in groups four, five and six were exposed to acetaminophen and pre-treated with methanol extract of Desmodium velutinum (MEDV) (100, 200 and 500 mg kg–1 b.wt., respectively). Afterwards, research team performed phytochemical analysis and studied the activities of glutathione-S-transferase, catalase (CAT), glutathione peroxidase, glutathione reductase (G-Red), reduced glutathione (GSH) as well as antioxidant vitamins (vitamins A, C and E) through standard procedures.
The outcomes of this experiments revealed that the methanol extract of D. velutinum stem bark consists of some bioactive compounds having antioxidant attributes which lessens the concentration of lipid peroxidation product in tested rats. However, further research is needed to inspect the long term impacts linked with its application.
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24 April, 2019