Causal agents of different ailments are becoming acclimatized and resistant towards new medication therapies with the passage of time; producing more challenges for experts. Accordingly, one of the most imperative multidrug-resistant (MDR) opportunistic Gram-negative bacteria is known as Klebsiella pneumonia, which is prevailing like a death angel in various parts of the world. Klebsiella pneumoniae belongs to Enterobacteriaceae strains which can generate Extended-Spectrum Beta-lactamases Enzymes (ESBLs). These particular strains are highly resistant to a range of antimicrobial drugs and therefore known as MDR bacteria1. This deadly culprit is causing various infections including pneumonia, Urinary Tract Infections (UTIs), burns infections and bacteremia therefore; leads towards high mortality rates2.
MDR bacteria and ESBL producing K. pneumoniae and other Gram-negative bacteria are circulating extensively both in hospitals and community3,4. Approximately; more than 390 different types of ESBLs have been identified globally, among which blaSHV, blaTEM and blaCTX-M were more rampant. Furthermore, MDR and ESBL producing K. pneumoniae strains can leads towards complications to cure a disease and ultimately cause treatment failure with various antimicrobials therapy e.g. beta-lactam, cephalosporins, aminoglycosides etc.5,6
Ahmed Abduljabbar and Haneen Mohammed conducted a research to evaluate the occurrence of MDR K. pneumoniae and ESBLs producing K. pneumoniae in isolates from inpatients with urinary tract infection and burns infections in Al-Kufa hospital in Al-Najaf province, Iraq. Because Iraq is a developing country and diagnosis of various infections is not an easy task due to bacterial resistance as well as deficient examination and limited published literature. Therefore, the aim of this study was to investigate K. pneumoniae strains and assess their antimicrobial resistance patterns. In this experiment, scientists collected 285 clinical samples from in-patients infected with urinary tract infection (141 urine samples) and burns infections (144 burns swabs). 14 different antibiotics were employed through disc diffusion technique as well as thirteen antimicrobials resistance genes were used by PCR (Polymerase chain reaction).
Total forty three K. pneumoniae strains were isolated and Ahmed and hannen noted the maximum resistance rate in case of amoxicillin 25 μg and amoxicillin+clavulanic acid 20+10 μg (97.67%). On the other hand, the minimum resistance rate was examined for imipenem 10 μg (9.30%). The most common resistance interlinked genes were blaSHV (86.04%) and IMP (9.30%) with inferior prevalence. Conclusively, Klebsiella pneumoniae strains isolated from burns infections were more potent as compared to urinary tract infections strains. This study will assist to control drug resistant bacteria but; deep investigation is needed for further achievements.
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12 December, 2018