Neurodegenerative disorders (ND) are prevailing like a virus now days and refer to the progressive and permanent damage of neuronal cells in particular area of the brain1, due to high cholesterol diets, pollution and metal overexposure. With the passage of time, these devastating ailments lead to several central nervous system (CNS) disorders, which affect above 30 million people globally. The most widespread ND include Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) as well as Huntington’s disease (HD)2.
These diseases are produced mostly because of oxidative stress, metal dyshomeostasis, mitochondrial dysfunction as well as dysfunctional trafficking of proteins3,4. Among these factors, oxidative stress is considered as a main reason of neurodegeneration5. Hence, scientists are hunting antioxidants to combat with this situation.
ND has multifactorial nature, so, therapy based on a single target is inadequate to control them. For this reason, mixture of different drugs is being utilized but it can be harmful because of amplification in toxicity by biotransformation. Therefore, experts introduced multi-target directed ligands (MTDLs) agents to modulate different targets; involved in the progress of pathological events6.
The most widespread group of MTDLs agents consists of chiefly cholinesterase inhibitors having additional characteristics that boost the pharmacological profile7. In this regard, natural products can be useful because they possess multimodal properties to treat neurodegenerative diseases8.
Accordingly, Erika A. Plazas9 and colleagues conducted in vitro antioxidant and anticholinesterase screening of 81 ethanolic extracts of 43 Colombian species including families ; Lauraceae, Piperaceae, Rutaceae and Myristicaceae to evaluate their neuroprotective potential. For this purpose, scientists examined the preliminary activity through TLC-bioautography assay with 2,2-Diphenyl-1-picrylhydrazyl (DPPH•), β-carotene and acetylcholinesterase (AChE). Moreover, the inhibitory effect (IC50) was assessed via microplate colorimetric test.
Scientists found the elevated DPPH antiradical scavenging effectiveness of C. cinnamomifolium, N. membranaceae as well as O. longifolia extracts (Lauraceae family). Moreover, 5 extracts of Zanthoxylum and Ocotea genus showed strong anticholinesterase activity inhibition of AChE, due to existenceof isoquinoline alkaloids. Conclusively, detailed investigation is needed to isolate and describe potential neuroprotective compounds.
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22 March, 2019