The process of aging is natural phenomenon that sometimes is occurred by due to onset of numerous diseases like; schizophrenia, cognitive impairment, Alzheimer’s, Parkinson’s diseases and others. Clear evidence is there that biological aging process is highly influenced by oxidative stress and damage1.
Excess production of reactive oxygen species (ROS) is deleterious to cells and is probably have toxic influences in cells implicated in the pathogenesis of some ageing diseases2.
Chitosan is an inborn polysaccharide having different amounts of (1-4)-glycosidic bonds3. It has attained much attention as a biomedical material and offers a wide variety of biological activities. Out of all Chitosan compounds, Chitosan nanoparticles (CHNPs) are of great importance as theses particles have immune-improving effect, antimicrobial and anticancer activity than those of particles of chitosan itself 4.
Lycopene (Ly) is a phytochemical belonging to carotenoid family. It is a red-colored pigment and a polar carotenoid5. It is adequately found in vegetables and fruits with red color as; tomatoes, pink grape-fruit, pink guava, watermelon and carrots6. Lycopene offers a range of exclusive biological characteristics possessing to its acyclic structure and major rate of double bonds.
Lycopene exhibits powerful neuro-curative agent, anti-proliferative and anti-inflammatory with preservation of normal cell metabolism, awareness improving characteristics, adjusting lipid metabolism in the blood. So, scientists conducted a new study purpose in order to explore the potential beneficial influences and the synergistic effect between CHNPs and Lycopene on D-gal (D-galactose-a physiological nourishing agent) using a rat model experiment7.
For this purpose researchers took male wistar rats and divided them into 9 groups. The CHNPs were characterized by transmission electron microscope. Zeta potential and size distribution of particles was also calculated. At the end of the experiment, some biochemical parameters were measured as lipid profile, tumor markers, inflammation markers, tissue damage LDH and CRP with histological, comet assay and TEM examination of liver tissues.
It was found that size distribution in chitosan was found. D-galactose induced hepatic biochemical alterations and cellular changes. CHNPs in two doses combined with Lycopene significantly obtained notable amelioration in liver enzymes biomarkers. The antioxidant enzymes were also enhanced.
It could be proved that CHNPs and Ly could synergistically afforded protection against liver injury and oxidative stress as a result of aging. Consequently, CHNPs was an effective agent in the drug delivery in liver diseases medications. CHNP-s and Ly enhanced liver enzymes and improved their antioxidant capacities in liver.
Written by: Rabeeia
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23 August, 2019