Atherosclerosis is a chronic disease and leading cause of death in developing countreis1. Arteries become hard and plaque formation occurs in this disease. It is characterized by cholesterol deposition in arteries, vessels’ inflammation and endothelium dysfunction2. These factors contribute to the insufficient blood supply to heart muscles and other parts of body3.
Many cardiovascular complications are induced by atherosclerosis such as; heart attack, ischemic heart disease and aneurysms etc4. Several factors are responsible for these cardiovascular events. These factors can be modified by improving life style, proper diet and avoiding smoking5.
Use of medicinal plants as an alternate remedy is getting common over last few decades. Murraya exotica commonly known as Orange Jessamine, is a traditionally used Chinese herbal medicine. In Chinese it is known as Chinese box6. It has been reported to exhibits properties like; anti-cancer, anti-diarrheal, anti-microbial and anti-thyroid7.
Investigators wanted to expand the research horizon and conducted a study on anti-atherosclerosis activity of Murraya exotica (ME) in hyper-cholesterolemic rats8.
Hypercholesterolemia was stimulated by nourishing atherosclerosis feed to the rats for the period of 4 weeks. The rats were then treated with ME during the hypercholesterolemia induction. Body weight, food and water intake was estimated every week till the end of procedure. However, at the end of procedure lipid profile in the blood and markers of liver and endothelial function and oxidative stress parameters were assessed in tissue homogenate.
Researchers demonstrated that treatment with ME decreased the %age gain in the body weight and food intake than negative control group. It was also observed that changed level of lipid profile get attenuated in ME treated group. Oxidative stress parameters and markers of endothelial and liver dysfunction in hypercholesterolemic rats were also changed.
It can be established that treatment with Murraya exotica ME produces anti-atherosclerogenic activity on the basis of its hyperlipidemic and antioxidant effect in hypercholesterolemic rats.
Written by: Rabeeia
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17 November, 2019