Cyperus rotundus is plant found in tropical, subtropical and temperate climates in countries like Egypt, Iraq, China, Tunisia and India. Commonly this plant is known as Saed, Seil in Arabic, nut grass, purple nut sedge in English and Xiang Fu in China1. Its fruit possess many properties and is used against diseases such as in gas prevention, diuretic, stomach issues, liver disorders, and refrigerant2.
Other pharmacological and biological properties reported includes; anti-Candida3, anti-inflammatory, antidiabetic4, antidiarrhoeal, antioxidant5, cytoprotective6, antimutagenic, antimicrobial, antibacterial7, cyto-toxic and apoptotic, anti-pyretic and analgesic activities8.
Angiogenesis is a procedure that occupies the configuration of new blood vessels from already accessible ones. This process is normally commenced within hypoxic tissues where additional new blood vessels are needed to sustain oxygenation and nutritional supply9.
In the disease setting environment, angiogenesis can stick on for months or years. Therefore scientists study the anti-angio-genic effect, phyto-chemical investigation and the free radical scavenging activity of Cyperus rotundus for various pharmacological purposes10.
For this researchers performed the extracted the ethanol extracts of plant and preliminary qualitative phytochemical analysis was conducted. After that ex vivo rat aorta ring assay was used to screen the extract for possible anti-angiogenic activity.
The ethanol extracts showed the significant dose-dependent blood vessels inhibition in comparison to the negative control. Significant free radical scavenging activity was also checked. Investigation of alcoholic extracts indicated the presence of various chemical constituents like alkaloids, glycosides, steroids, tannins, carbohydrates and flavonoids.
It can be said that the anti- angiogenic activity showed by the ethanol extract may be due to the presence of antioxidant compounds.
Written by: Rabeeia
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17 November, 2019