Pregnancy is a natural phenomenon which involves obvious changes in body, including reduced insulin sensitivity in peripheral tissues, increased pancreatic production of insulin and buildup and reallocation of body fat1. In the meantime, women enhance their energy intake and food quantity and maintain or reduce regular physical activity: alterations that can lead towards cardiometabolic diseases2.
Insulin resistance is produced in pregnancy in which maximum insulin sensitivity is reduced3. Insulin resistance is a diminished capability of cells to respond to the insulin action in transmission of glucose from bloodstream into muscles and other tissues4. On the other hand, there was observed no connection between parity and insulin resistance in a recent research5. Conversely, the influence of parity on metabolic syndrome in Chinese women showed that multiparity can cause metabolic syndrome6. Accordingly, it was discovered in similar investigation that amplified parity is linked with high cholesterol levels7 which may contribute to insulin resistance. Therefore, it is still not understood either parity promotes insulin resistance or not.
Kamal Eldin Ahmed Abdelsalam and Abdelsamee Alobeid M. Elamin conducted a research to determine the impact of grand multiparity, age and Body Mass Index (BMI) on insulin resistance in Sudanese women (representative of African women). Scientists also compared the levels of fasting glucose and insulin as well as insulin resistance in grand multiparas with primiparity and nulliparity. For this purpose, fasting blood samples were gathered from 100 non pregnant women as control group, 100 primiparity pregnant women and 100 grand multiparity pregnant women. Kamal and Abdelsamee determined the glucose (FBS) and insulin (FSI) proportions by Hitachi 912 full automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer procedure. Insulin resistance was calculated following the formula: FBG (mg dL–1)×FSI (μU mL–1)/405.
Scientists noticed major decline in glucose level in primiparity in comparison with control group. On the other hand, rise in glucose concentration was observed in multiparity ascompared to primiparity and non pregnant ladies. While, insulin exhibited considerably high levels in pregnant women and enhanced notably in grand multiparas comparing to primiparas and controls. Moreover, major boost in fasting insulin and reduction in insulin sensitivity with parity interlinked with age and obesity was determined as well. Therefore; researchers concluded that grand multiparity amplify the risk factors of insulin resistance (HOMA-IR).
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23 August, 2019