Moringa oleifera or commonly known as Moringa is possess many medicinal properties and is found in tropical and sub-tropical countries1. Anti-oxidant analysis showed the presence of some major active compounds includes; polyphenols, generally, the flavonoids, myrecytin, quercetin and kaempferol2.
Several studies have reported hepatoprotective effect of M. oleifera L. leaves extract against several hepatotoxic drugs and chemicals including acetaminophen, alloxan, nickel, diclofenac sodium, carbon tetrachloride and alcohol3, 4.
Methotrexate (Meth) is a folic acid and is one of the most commonly utilized anticancer agents. Meth is widely used to treat many types of tumor including; leukemia and lymphoma. Currently, Meth has been used as an immunosuppressant agent to treat rheumatoid arthritis as well as a vast variety of inflammatory disorders5. As anti-proliferative agent, Meth causes large extent of toxicity to the lungs, blood and liver.
From hepatotoxicity point of view, Meth-induced hepatotoxicity is widely studied and used moel by researchers. Free radicals and oxidative stress are considered to play role in the mechanisms of Meth-induced hepatotoxicity6.
Relying upon the fact that the M. oleifera L. extract to contain many antioxidants, which are believed to cause a protective effect against hepatotoxicity induced by Meth scientists conducted a new study. They evaluated the possible hepatoprotective effect of M. oleifera L. leaves extract against Meth-induced hepatotoxicity. In addition, the mechanism of the suggested effect was studied regarding the potential antioxidant properties of leaves extract7.
In order to evaluate that, researchers took 2 rats and divided into 4 groups; control group, hepatotoxic (Meth) group, M. oleifera group and pre-treatment Meth group. Hepatotoxicity was induced. Serum concentration of liver enzymes and inflammatory cytokines were measured. Liver contents of oxidative stress markers and antioxidant enzymes were determined. Hematoxylin and eosin (H and E) stained liver sections from all groups were also examined.
It was observed that M. oleifera doses significantly reduced serum liver enzymes, serum inflammatory cytokines and liver oxidative stress markers compared to Meth group. 500mg of M. oleifera decreased Meth-induced pathological changes in liver while 700mg perfectly protected the liver against Meth-induced pathological changes.
It was established and proved that the M. oleifera L. extract has protective action against Meth-induced acute liver damage through an antioxidant and anti-inflammatory mechanism.
Written by: Rabeeia
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17 November, 2019