Scientists have studied 2 traditional medicines and checked their effects on wound healing. It was found that Bismuth subgallate (BSG) and Borneol (BO) have efficiency on wound therapy by suitable combination1.
Bismuth subgallate (BSG) and Borneol (BO) are traditionally used medicines. BSG firstly was used in brain malfunctions2 and removal of tonsils3 for reducing the clotting time in post-operative haemorrhages. Recently it is also used as a topical hemostatic agent on palatal wounds4.
Bornel (BO) is used for analgesia in traditional Chinese and Japanese medicine and is found in the essential oil and exerts antimicrobial and anti-oxidation functions5.
Wound healing is a multi-complex process. For this purpose combination of drugs is used to activate in sequence in wound healing. The BSG have advantageous consequence on coagulation which is one of an essential phase in wound healing process. The combination of BSG and BO could stimulate granulation tissue formation and reorganization of epithelial tissues in a full-thickness wound model6.
Therefore, signifying that BSG and/or BO alone or combination of these two drugs might modulate fibroblast proliferation and/or migration. As these are critical steps in wound repair. Scientists indicated that BSG combined with BO at suitable ratio has better effect on fibroblasts proliferation and migration stimulation than by BSG/BO alone1.
It was found that suitable specific ratio of BSG combined with BO have more efficiently on fibroblasts proliferation and migration than BSG/BO alone. Moreover, BSG combined with BO induced migration and filopodia formation through PI3K pathway. Id1 mRNA expression was increased by optimal ratio of BSG combined with BO.
It was indicated in this investigation that the suitable combination of BSG and BO stimulated fibroblastic proliferation and migration which suggests these two traditional medicines also have efficiency on wound therapy by suitable combination.
Written by: Rabeeia
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17 November, 2019