Osteoporosis is a chronic disease affecting bone mass density (BMD), bone porosity, structure and quality. It is of 2 types i.e. primary (post-menopausal), and secondary type. Primary one is the most common one with 80 to 95 percent ratio in females with post menopausal1.
The prevalence rate of osteoporosis is high in senior women (post-menopausal) than men, due to estrogen interaction. The onset of osteoporosis depends on multiple factors however, lack of estrogen, inflammation (cytokines) are the critical factors contributing to osteoporosis2, 3.
Salvia miltiorrhiza (Red sage) is a herbal plant which is also known as danshen in Chinese. This plant contains hydrophilic phenolic compounds known as; Salvianolic acid A (SAB-A) and Salvianolic acid B (SAB-B). Roots of this plant are used to treat many ailments in Traditional Chinese Medicine (TCM). It is a well-known hemorrheologic drug (increase blood flow) as well as to protect heart, liver, bones and brain4.
Salvianolic acid B SAB-B is of immense attention due to its different pharmacological properties like cardio-protective, neuro-protective, gastro-protective, reno-protective and hepatoprotective5.
Previously few researchers have demonstrated that salvianolic acid B would promote osteogenesis or bone loss in both cell line and animal model6. However in a new study scientists wanted to study its effects against ovariectomy (Removed ovary) induced osteoporosis.
Therefore, the study was intended to explore the anti-osteoporotic effects of SAB-B by evaluating the Bone Mineral Density/Content (BMD/BMC), bone markers, inflammatory markers and bone biomechanical stability7.
For this purpose 40 female rats were randomly chosen and divided into four groups. Rats were treated with different concentrations of SAB-B. The results showed that treatment with SAB-B (20 or 40 mg kg–1), substantially increased the body weight than ovariectomy rats. Bone Mineral Density/Content (BMD/BMC) and body weight were also increased in SAB-B treated group.
Bone markers as well as inflammatory markers concentrations were significantly eliminated after 12 weeks of administration with SAB-A in ovariectomy rats. Furthermore, the bone biomechanical stability was notably improved upon supplementation with SAB-B.
It was concluded that concentrations of SAB-B, 20 and 40 mg kg–1 treatment revealed effective anti-osteoporotic activity. However, SAB-B 40 showed higher anti-osteoporotic activity than SAB-B 20. Therefore, SAB-B would be recommended for treating post-menopausal osteoporosis with other standard drugs.
Written By: Rabeeia
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23 August, 2019