Alzheimer’s disease is one of prevailing neurodegenerative disease characterized by cognitive impairment and changes in personality orientation leading to dementia1.
There are many underlying factors responsible for this disease and treatments available to cure dementia or cognitive dysfunction. There are studies that suggest that suggest the administration of general anesthesia observe a higher incidence of Alzheimer’s disease in aged patients which increased risk rate2.
Sevoflurane is a normally used clinical anesthetic compound, but the safety and accurateness of its dosage vary from experiment to experiment3. Furthermore, there are no actual reports or evidence of sevoflurane inhalation anesthesia which have a negative influence on the (CNS) Central Nervous System2. Therefore, it was necessary for scientists to investigate the underlying mechanism of sevoflurane inhalational anesthesia by detecting its biological target4.
Researchers used the rat model and performed experiment on 60 aged rats. Rats were exposed to sevoflurane anesthesia and were assessed for different biological and biochemical markers.
It was observed that sevoflurane stimulated long term spatial memory in aged rats. This inspection was based on the assessments of the certain protein related with Alzheimer’s disease such as beta-amyloid protein in the aged rat’s hippocampus. It was also observed that the sevoflurane anesthesia was not accountable for the spatial memory mutilation because the speed of the rats swimming in the water was not affected even by the test exposures. Thus, indicating that the motor discrepancy were not the chief factor for cognitive impairment.
Regarding the intricate matters authors explained:
“Our study observed that sevoflurane anesthesia was associated with cognitive decline in aged rats. This is because; the APP mRNA expression was significantly higher in the hippocampus of the aged rats thereby depleting the APP protein. Thus promoting the oligomerization of Aβ42 peptide, which is toxic to the neuronal cells thereby contributing to cognitive impairments. The study also recommends that the present findings on sevoflurane anesthesia should be further noted by future researchers and scientists to elucidate the pathogenesis of Alzheimer’s disease in aged patients.”
Written by: Rabeeia
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22 August, 2019