Chemical pesticides applications have grown significantly around the world with increasing yields which in turn needs controlling pests. These compounds assured good agricultural production but can raise serious concerns because of poor application measures and lack of caution in practice. The overuse of traditional pesticides can cause serious pollution to the agro-ecosystem, mammalian toxicity and threaten non-target organisms that were beneficial to the environment1.
There has been an outburst in the development and application of engineered nano-materials (ENM) resulting from an over-the-top increase in exposure to humans. Whereas, ENM can give positively to quality of lives by providing improved materials, products, medical devices, drug delivery systems, etc., there is an urgent need to understand the potential health risks related with exposure to such materials2.
Nano-particles help to produce new pesticides and insect repellants. Previously the action effect of a mixture of two nano-particles with two insecticides to the pest mite had been studied3. Undesirable effects of nano-particles are catching the considerable attention and growing worldwide recognition.
Nano-particles ingested via water, food, cosmetics, drugs, drug delivery devices, etc. Uptake of particles of different dimensions via the gastrointestinal tract induces unlike bad effects4. There are many few studies on toxic effects of nano particles on animals. Therefore a new study was conducted to check their adverse effects on albino rats.
The study aimed to investigate the comparative toxicity of two nanoparticles (NPs); nano-silica and nano-copper oxide with two insecticides; methoxyfenozide and profenofos against albino rats5.
he results showed that there was a significant difference in body weight between all treatments with each other. Also all tested compounds caused a significant increase in all evaluated parameter (liver and kidney functions) concentrations. Also, necrosis of some cells of the proximal convoluted tubules and the nuclei of these cells are pyknotic was observed. Methoxyfenozide caused the highest effect followed by profenofos while two nanoparticles had a less toxic effect.
Bio-distribution experiments have showed liver, kidney and spleen as the target organs for engineered nanoparticles after uptake by the gastrointestinal tract. Therefore, it is concluded that the effect of NPS on the tissues may cause organ toxicity in animals.
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23 August, 2019