Depression is one of most common psychiatric disorder easily processed by inflammation1. It has been reported that certain pro-inflammatory cytokines are found in blood and cerebrospinal fluid of depressive patients2. More than 350 million people suffer from this disorder worldwide and 1.5-19% people suffer from it throughout their life3.
In previous studies it has been reported that cytokines and Lipopolysaccharide (LPS) are responsible for depression like behavior in animals4. A large of anti depressant used have slow effect that take about 6 to 8 weeks for producing prominent response5. Other factors influencing the activity of anti-depressants are major side effects and drug-drug interactions6.
Triptolide (TPL) is the major compoenet of a Chinese herb. It has been used traditionally for treatment various inflammatory ailments in China. Many studies have shown its anti-inflammatory, antitumor and immunosuppressive features7. These properties of triptolide led the researchers to evaluate the effect of Triptolide (TPL) on depressive like behavior induced by lipopolysaccharide (LPS) in mice8.
It was found that treatment of mice with TPL attenuates the behavioral parameters affected by LPS. Pro-inflammatory cytokines and oxidative stress parameters levels were significantly decreased in the hippocampus and prefrontal cortex. Plasma concentration of corticosteroid significantly decreased. The level of Brain-derived neurotrophic factor (BDNF) in brain tissue increased significantly in TPL treated group than negative control group of mice.
From the study it can be determined that the treatment with Triptolide (TPL) attenuates the depressive behavior by decreasing the level of cytokines and oxidative stress parameter in the brain tissues of Lipopolysaccharide LPS challenged mice.
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23 August, 2019