Olive pomace (OP) is extracted from oil and is considered as one of the most widespread and important agro-industrial by-products. It contains an abundant amount of useful substances, such as phenolic compounds that have different valuable activities including antioxidant, anti-microbial, anti-inflammatory as well as anticancer1.
Phenolic compounds are precious compounds and can be used to restrain certain health related issues. Hence, supplementation of this particular substance can be used for the augmentation of functional foods to enhance their activity in promoting human health. Moreover, they can also be used as potential products to amplify shelf life of food items.
Therefore, a suitable procedure to extract compounds having antioxidant activity from olive pomace that would be a good approach to maximize the use of food processing wastes. Accordingly, ultrasound-assisted extraction (UAE) is being used for this purpose which is one of the best methods for phenolic extraction from olive pomace2.
This approach can be effective in case of diabetes. Diabetes mellitus is a threatening disease in which zero or insufficient insulin is produced in the body, which leads to high blood glucose levels. It is becoming a serious international public health problem3.
However, it is reported that gut microbiota are crucial in diabetes4, as they play a key role to balance the glucose via several different bacterial metabolites5. Additionally, probiotics are reported to restrain gluconeogenesis in type 2 diabetic mice6. Hence, a combination of phenolic compounds and probiotics in a food product may treat T2D.
These facts urged researchers to study the anti-diabetic effect of yoghurt in combination with probiotics as well as olive pomace extract in diabetic rats. For this purpose, the ultrasonic-assisted procedure was employed to extract OP and then its total phenolic content and antibacterial activity was assessed. Afterwards, scientists collected the blood samples to check plasma glucose, insulin, lipid profile, plasma markers of oxidative stress, tumor necrosis factor-α, liver as well as kidney functions7.
This investigation revealed that olive pomace extract (OPE) shows antimicrobial and antioxidant activities. In this study, yoghurt supplemented with probiotics and OPE exhibited an anti-diabetic effect in type-2 diabetes and Yoghurt supplemented with OPE 1.5% was found to be the best combination in this regard. Conclusively, yoghurt containing phenolic compounds from OP and probiotics can be used to treat type-2 diabetic patients.
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