In a new study scientists have demonstrated that a compound Vanillic Acid may have potentially better neuroprotective activity by improving neuron function through attenuation of inflammatory flow1.
Vanillic acid is a derivative compound found in roots of “female ginseng”2. It is the oxidative product to vanillin. It is commonly used as a flavoring agent in food inductor due to its creamy and pleasant odor3.Several experimental studies has demonstrated its biological properties such as antioxidant, anti-inflammatory, anti-tumor activities4 as well as act as hepatoprotective, gastroprotective and nephroprotective agent5.
One of the deadliest strokes is Ischemic stroke with thromboembolic occlusion of middle or central cerebral artery6. At present only recombinant tissue Plasminogen Activator (rtPA) is the acceptable therapeutic strategy for treating stroke. However, the usage of rtPA is much limited due to the risk of many contraindications and intra-cerebral hemorrhage7. Therefore, the need of an effective treatment to combat stroke related abnormalities is in greater demand.
In recent years no study has been conducted with vanillic acid against the cerebral ischemia-reperfusion model. Scientists were intended to to assess the neuro-therapeutic effect of vanillic acid followed by MCAO induced focal cerebral ischemic reperfusion injury in a rat model1.
For this purpose 40 healthy rats were divided into 4 groups and the effects were checked. In this pre-clinical study it was found that Vanillin acid could progress neurological motor ability through eliminating neuron damage and thus dropping the cerebral infarct by improving the antioxidant status and reducing inflammatory response.
It was also observed that it could adapt the expression of different inflammatory factors allied to NF-κB signaling pathway. Authors have suggested that further studies are still required to prove its procedure and evaluate the detailed mechanism underlying the neuroprotective activity of Vanilliic acid.
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