Therapeutically effective and important materials have always been a great interest in nanotechnology world. Making different compounds from nano-material have a vast usage range1.
Current biomedical and engineering demands have been answered with key innovations based on nanoparticles2. Apart from feasibility in altering their chemical properties for specific use, nanoparticle of metal or their oxides withstand rigorous processing conditions that makes them too attractive segment in nanotechnology research fields3.
Different materials have been used in the manufacturing of nanoparticles and are covered by with different materials. Zein, a principle protein of maize is also reported to be a promising material for film coating especially for preparation of micro or nanoparticles and nanowires of other metals such as magnesium oxide (MgO)4.
Literature review described that ZnO nanoparticles encapsulated in chitosan and polyvinyl alcohol based films and evaluated for their antibacterial activity especially on the species S. aureus5. ZnO based nano-rods were assessed for their potential as filler in starch-based films for its use as active packaging materials in the pharmaceutical and food industries6. Even green ZnO nanoparticles were synthesized, that exhibited inhibition against bacterial and fungal pathogens, therefore can to be used effectively in agricultural and food safety applications7.
In a new study researchers synthesized the ZnO nanoparticles were synthesized and coated them using natural corn polymer zein. The prepared zein coated nanoparticles were characterized for physiochemical properties and evaluated for their role in stabilization, in-vitro release and percentage effective inhibition of bacterial and fungal strain in comparison to the uncoated ZnO nanoparticle formulation8.
Zein based ZnO nanoparticles were synthesized using hydrothermal technique. Both zein coated and uncoated nanoparticles were distinguished for particle size, surface charge, morphology, crystalline nature and metal oxide compatibility reportes. In vitro closure studies were performed in order to determine the effect of zein over the solubility and release of ZnO nanoparticles. Antimicrobial assay for the zein coated ZnO nanoparticles were also a number performed.
It was found that the synthesized zein coated ZnO nanoparticles were found to be highly crystalline with enhanced solubility and better compatibilities. Among the four microbial strains tested, zein coated ZnO nanoparticles exhibited higher pharmacological activity against C. albicans strains in comparison to the uncoated. These experimental outcomes can indicate the potential of ZnO nanoparticles in formulating an antimicrobial dental aid.
Written by: Rabeeia
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17 November, 2019