Are "Forever Chemicals" Harming Our Kidneys? Study Reveals Link to Long-Term Damage

Published at: November 9, 2024 2:17 PM

A new study suggests that “forever chemicals”—toxic pollutants found in everything from rain to our own bloodstreams—might be damaging kidney health by affecting the gut microbiome. Known as PFAS (per- and polyfluoroalkyl substances), these chemicals are widely used in non-stick cookware, fabrics, cosmetics, and food packaging, and they are nearly impossible to avoid. They resist breaking down and remain in the environment and our bodies for years.

The kidneys are vital to filtering excess water and toxins from the blood, and exposure to forever chemicals may be disrupting these essential "drains" in our bodies. Some researchers are even concerned that this buildup could contribute to chronic diseases and cancer.

The study, conducted at the University of Southern California, followed 78 young adults over four years. Participants with higher levels of PFAS exposure were found to have reduced kidney function, evidenced by a 2.4% drop in serum creatinine levels—an indicator of kidney health. This finding is especially concerning for young adults, a critical time for kidney development.

PFAS exposure also seems to disrupt gut bacteria, potentially leading to inflammation and oxidative stress, which may further damage kidney health. Blood and stool samples from participants showed that changes in two types of gut bacteria explained up to half of the reduced kidney function related to these chemicals.

PFAS are no longer produced in the U.S., but their presence lingers, with more than 12,000 variants still in use worldwide. While only a few of these chemicals are directly linked to diseases like cancer, cardiovascular issues, and birth defects, their effects on kidney function may be broader than previously known.

This study offers initial evidence that forever chemicals might harm kidney function by affecting gut health. Future research will be crucial to understand the full impact of these chemicals on human health and how best to protect ourselves.